A GARBAGE truck has veered across a major road and smashed into a house in Sydney’s south-west, causing significant structural damage, police say.

The garbage truck was headed south on the Camden Bypass about 10.30am (AEDT) today when the incident occurred.

Police said the male Driver veered across four lanes of traffic onto the incorrect side of the road.

The truck then mounted the kerb and crashed into the rear of the house on Shoemark Place, causing significant structural damage.

Two people home at the time were not injured.

The Truck driver was treated at the scene for minor injuries.

Police said it was not yet clear what may have caused the incident.

The company that operated the Truck, SITA Environmental Solutions, said it would conduct an internal investigation into the incident.

Company spokesman Mike Ritchie promised to provide temporary accommodation for the residents of the damaged house.

“This sort of accident is of course a great shock to those affected and the family’s needs will be taken care of,” Mr Ritchie said.

The company would cooperate with the police investigation, he said.